A new type of DNA phosphorothioation-based antiviral system in archaea

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成果类型：

期刊论文

作者：

Xiong, Lei;Liu, Siyi;Chen, Si;Xiao, Yao;Zhu, Bochen;...

通讯作者：

Chen, Shi

作者机构：

[Zhang, Yujing; Wang, Lianrong; Gao, Yali; Deng, Zixin; Liu, Siyi; Xiao, Yao; Xiong, Lei; Chen, Shi; Zhu, Bochen] Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China.

[Wang, Lianrong; Luo, Jie; Xiong, Lei; Chen, Shi] Hubei Univ Med, Taihe Hosp, Shiyan 442000, Hubei, Peoples R China.

[Zhang, Yujing; Wang, Lianrong; Gao, Yali; Liu, Siyi; Xiao, Yao; Xiong, Lei; Chen, Shi; Zhu, Bochen] Wuhan Univ, Brain Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.

[Chen, Si] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.

[Chen, Beibei; Chen, Xiangdong] Wuhan Univ, Coll Life Sci, Wuhan 430071, Hubei, Peoples R China.

通讯机构：

[Chen, Shi] W

[Chen, Shi] H

Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China.

Hubei Univ Med, Taihe Hosp, Shiyan 442000, Hubei, Peoples R China.

Wuhan Univ, Brain Ctr, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.

语种：

英文

期刊：

Nature Communications

ISSN：

2041-1723

年：

2019

卷：

期：

页码：

1688-null

DOI：

10.1038/s41467-019-09390-9

基金类别：

We sincerely thank Li Huang, Hua Xiang, Changsheng Zhang, Hao Bian and Qian Tan for their valuable suggestions and help with our experiments. We sincerely thank Dr. Suzanna Brauer for providing the DNA sample for M. boonei 6A8. This work was supported by grants from the National Science Foundation of China (31720103906, 31520103902 and 31670072). The work of Xiangdong Chen was supported by grants from the National Science Foundation of China (31570174).

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Archaea and Bacteria have evolved different defence strategies that target virtually all steps of the viral life cycle. The diversified virion morphotypes and genome contents of archaeal viruses result in a highly complex array of archaea-virus interactions. However, our understanding of archaeal antiviral activities lags far behind our knowledges of those in bacteria. Here we report a new archaeal defence system that involves DndCDEA-specific DNA phosphorothioate (PT) modification and the PbeABCD-mediated halt of virus propagation via inhibition of DNA replication. In contrast to the breakage...

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A new type of DNA phosphorothioation-based antiviral system in archaea

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