Computational analysis of AnmK-like kinase: New insights into the cell wall metabolism of fungi

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成果类型：

期刊论文

作者：

Dai, Jianghong*;Qu, Hong;Yu, Zhisheng;Yang, Jiangke;Zhang, Hongxun

通讯作者：

Dai, Jianghong

作者机构：

[Dai, Jianghong; Yang, Jiangke] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

[Dai, Jianghong; Yu, Zhisheng; Zhang, Hongxun] Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China.

[Qu, Hong] Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Ctr Bioinformat, Beijing 100871, Peoples R China.

[Dai, Jianghong] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, 68 Xuefu Rd S, Wuhan 430023, Peoples R China.

通讯机构：

[Dai, Jianghong] W

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, 68 Xuefu Rd S, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

1,6 anhydro beta dextro glucosamine;1,6 anhydro n acetylglucosamine;1,6 anhydro n acetylmuramic acid kinase;aspartic acid;glucosamine;levoglucosan kinase;phosphotransferase;unclassified drug;fungal protein;phosphotransferase;chitin;coliform bacterium;fungus;homology;hydrolysis;metabolism;phylogenetics;Article;computational analysis;enzyme analysis;fungal cell wall;hydrolysis;Lipomyces;Lipomyces starkeyi;molecular docking;phylogenetic tree;priority journal;sequence alignment;sequence analysis;cell wall;enzymology;genetics;metabolism;phylogeny;procedures;Escherichia coli;Fungi;Lipomyces starkeyi;Cell Wall;Fungal Proteins;Lipomyces;Phosphotransferases;Phylogeny;Sequence Analysis, Protein

期刊：

Journal of Theoretical Biology

ISSN：

0022-5193

年：

2015

卷：

379

页码：

59-65

DOI：

10.1016/j.jtbi.2015.05.004

基金类别：

We thank anonymous reviewers for valuable comments and suggestions to improve the manuscript. This work was supported by the Research Fund of Wuhan Polytechnic University (no. 2010RZ15 ) and the Natural Science Foundation of Hubei Province (no. 2011CDB227 ).

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与技术学院

摘要：

1,6-Anhydro-N-acetylmuramic acid kinase (AnmK) is the unique enzyme that marks the recycling of the cell wall of Escherichia coli. Here, 81 fungal AnmK-like kinase sequences from 57 fungal species were searched in the NCBI database and a phylogenetic tree was constructed. The three-dimensional structure of an AnmK-like kinase, levoglucosan kinase (LGK) of the yeast Lipomyces starkeyi, was modeled; molecular docking revealed that AnmK and LGK are conserved proteins, and 187Asp, 212Asp are enzymatic residues, respectively. Analysis suggests that ...

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Computational analysis of AnmK-like kinase: New insights into the cell wall metabolism of fungi

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