期刊论文

Peng, Lijuan

英文

Journal of Proteomics

1874-3919

2014

103

267-278

10.1016/j.jprot.2014.03.023

[R01 CA122320]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01CA122320, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, 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P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598, P30CA077598] Funding Source: NIH RePORTER

本校为第一且通讯机构

Heterocyclic aromatic amines (HAAs) are carcinogens formed during the cooking of meats or arise in tobacco smoke. The genotoxic N-oxidized metabolites of HAAs bind to Cys residues of proteins to form arylsulfinamide adducts. However, these adducts are unstable and undergo hydrolysis during enzymatic digestion, and thus have been precluded as biomarkers of exposure to HAAs. Arylsulfinamide adducts of HAAs can undergo oxidation to form stable arylsulfonamide linkages, which are chemically stable and amenable for analysis. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogen pre...