Comparative pharmacokinetics of doxycycline in crayfish (Procambarus clarkii) following oral, intramuscular, and intrasinus administrations

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成果类型：

期刊论文

作者：

Xu, Ning*;Sun, Weiyu;Gong, Lve;Liu, Yongtao;Dong, Jing;...

通讯作者：

Xu, Ning;Ai, XH

作者机构：

[Xu, Ning; Liu, Yongtao; Ai, Xiaohui; Sun, Weiyu; Yang, Yibin; Ai, XH; Dong, Jing; Gong, Lve; Zhou, Shun] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China.

[Liu, Yongtao; Ai, Xiaohui; Xu, Ning; Yang, Yibin; Dong, Jing; Zhou, Shun] Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qua, Wuhan, Peoples R China.

[Liu, Yongtao; Ai, Xiaohui] Minist Agr & Rural Affairs, Key Lab Control Qual & Safety Aquat Prod, Beijing, Peoples R China.

[Sun, Weiyu] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Xu, N; Ai, XH ] C

Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China.

语种：

英文

关键词：

Bioavailability;Crayfish;Different administrations;Doxycycline;Pharmacokinetics

期刊：

Aquaculture

ISSN：

0044-8486

年：

2022

卷：

551

页码：

737941

DOI：

10.1016/j.aquaculture.2022.737941

基金类别：

The authors would like to appreciate the Major Technological Innovation of Hubei Province of China ( 2019ABA077 ) and the financial support from the National Natural Science Foundation of China ( 32173022 ).

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

The objective of the present study was to investigate the pharmacokinetic (PK) properties of doxycycline (DC) in crayfish after three different drug administrations of oral (per os, P.O.) gavage, intramuscular (IM) injection, and intrasinus (IS) injection at a dose of 20 mg/kg at 24.0 °C. Samples of hepatopancreas, muscle, gill, and hemolymph were collected at pre-determined time points after cessation of drug treatment (n = 5 for per time point). DC concentrations were determined by high-performance liquid chromatography with an ultraviolet d...

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Comparative pharmacokinetics of doxycycline in crayfish (Procambarus clarkii) following oral, intramuscular, and intrasinus administrations

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