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Edaravone rescues the lung by inhibiting lipid peroxidation and pro-inflammatory cytokines in a rat model

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成果类型:
期刊论文
作者:
Wu Zhouyang;Ming Yu;Zhang Zhao;Wu Jing;Wu Zhilin;...
通讯作者:
Yao Shanglong
作者机构:
[Wu Jing; Yao Shanglong; Wu Zhilin; Wu Zhouyang; Zhang Zhao] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesia & Crit Care, Wuhan 430022, Hubei, Peoples R China.
[Ming Yu] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430022, Hubei, Peoples R China.
通讯机构:
[Yao Shanglong] H
Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesia & Crit Care, Wuhan 430022, Hubei, Peoples R China.
语种:
英文
关键词:
acute lung injury;edaravone;free radical scavenger;inflammation
关键词(中文):
急性肺损伤;脂质过氧化;大鼠模型;细胞因子;依达拉奉;活性氧物种;病理生理学;DNA损伤
期刊:
中华医学杂志(英文版)
ISSN:
0366-6999
年:
2014
卷:
127
期:
5
页码:
968-970
机构署名:
本校为其他机构
院系归属:
医学与健康学院
摘要:
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a frequent complication in critically ill patients and cause significant mortality. Effects of reactive oxygen species (ROS) on alveolar epithelial cells are involved in the pathophysiology of ALI/ARDS. ROS can provoke DNA damage, lipid peroxidation, and activation of various genes coding for ...
摘要(中文):
Acute lung injury/acute respiratory distress syndrome(ALI/ARDS)is a frequent complication in critically ill patients and cause significant mortality.1 Effects of reactive oxygen species(ROS)on alveolar epithelial cells are involved in the pathophysiology of ALI/ARDS.ROS can provoke DNA damage,lipid peroxidation,and activation of various genes coding for proteins involved in inflammation and cell damage.Edaravone(3-methyl-1-phenyl-2-pyrazoline-5-one)is a potent free radical scavenger and has the ability to inhibit lipid peroxidation,thus e...

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