Integration of Metabolomics, Lipidomics, and Proteomics Reveals the Metabolic Characterization of Nonalcoholic Steatohepatitis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Ji*;Yang, Yiqin;Wang, Zipeng;Zhang, Xiaofen;Zhang, Yingfan;...

通讯作者：

Zhang, Ji;Tian, X;Bao, J

作者机构：

[Zhang, Ji; Tian, Xin; Yang, Yiqin; Du, Yue; Wang, Suhua; Zhang, J] Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou 450052, Peoples R China.

[Zhang, Ji; Tian, Xin; Yang, Yiqin; Du, Yue; Wang, Suhua; Zhang, J] Zhengzhou Univ, Henan Key Lab Precis Clin Pharm, Zhengzhou 450052, Peoples R China.

[Wang, Zipeng] Zhengzhou Univ, Affiliated Hosp 1, Dept Thyroid Surg, Zhengzhou 450052, Peoples R China.

[Zhang, Xiaofen] Zhengzhou Univ, Affiliated Hosp 1, Dept Gynecol, Zhengzhou 450052, Peoples R China.

[Zhang, Yingfan] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Peoples R China.

通讯机构：

[Tian, X ; Bao, J ; Zhang, J] Z

Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou 450052, Peoples R China.

Zhengzhou Univ, Henan Key Lab Precis Clin Pharm, Zhengzhou 450052, Peoples R China.

Zhengzhou Univ, Affiliated Hosp 1, Dept Gastroenterol, Zhengzhou 450052, Peoples R China.

语种：

英文

关键词：

nonalcoholic steatohepatitis;targeted metabolomics;lipidomics;proteomics;metabolic disturbance;cholestyramine

期刊：

JOURNAL OF PROTEOME RESEARCH

ISSN：

1535-3893

年：

2023

卷：

期：

页码：

2577-2592

DOI：

10.1021/acs.jproteome.3c00009

基金类别：

Henan Province Science and Technology Attack Project [222102310023]; Key Projects of Medical Science and Technology in Henan Province [SBGJ202102083]; Foundation for Basic Research and Cultivation of Young Teachers of Zhengzhou University [JC22862050]; National Natural Science Foundation of China [32170594, 82002552]; National Human Genetic Resources Sharing Service Platform [2005DKA21300]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Metabolic dysfunction is associated with nonalcoholic steatohepatitis (NASH) development. However, omics studies investigating metabolic changes in NASH patients are limited. In this study, metabolomics and lipidomics in plasma, as well as proteomics in the liver, were performed to characterize the metabolic profiles of NASH patients. Moreover, the accumulation of bile acids (BAs) in NASH patients prompted us to investigate the protective effect of cholestyramine on NASH. The liver expression of essential proteins involved in FA transport and lipid droplets was significantly elevated in patien...

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Integration of Metabolomics, Lipidomics, and Proteomics Reveals the Metabolic Characterization of Nonalcoholic Steatohepatitis

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