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1-Laurin-3-Palmitin as a Novel Matrix of Solid Lipid Particles: Higher Loading Capacity of Thymol and Better Stability of Dispersions Than Those of Glyceryl Monostearate and Glyceryl Tripalmitate.

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成果类型:
期刊论文
作者:
Shi, Hao;Huang, Shuangshuang;He, Junbo*;Han, Lijuan;Zhang, Weinong*;...
通讯作者:
He, Junbo;Zhang, Weinong
作者机构:
[He, Junbo; Zhang, Weinong; He, JB; Zhang, WN; Shi, Hao; Han, Lijuan; Huang, Shuangshuang] Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.
[He, Junbo; Zhang, Weinong; He, JB; Zhang, WN; Han, Lijuan] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.
[Zhong, Qixin] Univ Tennessee, Dept Food Sci, Knoxville, TN 37996 USA.
通讯机构:
[He, JB; Zhang, WN] W
Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.
Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
1-laurin-3-palmitin;delivery system;solid lipid nanoparticles;thymol
期刊:
Nanomaterials
ISSN:
2079-4991
年:
2019
卷:
9
期:
4
页码:
489
基金类别:
Funding: This research was funded by Hubei Provincial Natural Science Foundation of China (No. 2018CFB356), National Natural Science Foundation of China (No. 21807084), and Research and Innovation Initiatives of WHPU (2018Y02). Q.Z. acknowledge hatch projects TEN00487 and 223984 supporting his time spent on this work.
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
To develop solid lipid nanoparticles (SLNs) with a new lipid matrix for delivery of hydrophobic bioactive molecules, high purity 1-laurin-3-palmitin (1,3-LP) was synthesized and the prepared 1,3-LP SLNs were compared with those of two common SLN matrices in glyceryl monostearate (GMS) and glyceryl tripalmitate (PPP). Conditions of preparing SLNs were first optimized by evaluating the particle size, polydispersity index (PDI), zeta-potential, and stability. Thereafter, the performance of SLN loading of a model compound in thymol was studied. The...

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