NOTCH1 signaling pathway is very important for body development and the study of functions of NOTCH 1 target genes is helpful to understand molecular mechanisms .The activated fragment of NOTCH1,ICN1,enters the cell nucleus and recruits its partners ( co-activators):CSL and MAML1,to form a DNA-binding complex and initi-ates the transcription of NOTCH1 target genes.Bioinformatics predicts that there are 21 new possible NOTCH1 tar-get genes.The results of semi-quantitative PCR,real-time quantitative PCR ,and protein expression ...
