期刊论文

Proceeding of deubiquitinase study

中文

武汉轻工大学学报

2095-7386

2016

35

3

1-12

10.3969/j.issn.2095-7386.2016.03.001

本校为第一机构

泛素化和去泛素化是两种广泛存在的蛋白质翻译后修饰方式。阐述了其影响了目标蛋白在细胞内的定位、稳定性和功能。其中,去泛素化过程涉及组蛋白的修饰,细胞周期,细胞分化,细胞凋亡,内吞和自噬的调控及DNA损伤修复,也参与机体的肿瘤发生,肌肉萎缩,组织发育及抗病毒感染。

Ubiquitination and deubiquitination are two popular styles of post-translation modification of protein . These two modifications affect intracellular localization , stability and functions of target proteins .And the process of deubiquitination is involved in the modification of histone , cell cycle , cell differentiation , cell apoptosis , endocyto-sis, autophagy and DNA repair after damage , and it is also involved in the procedures of carcinogenes...