This paper proposed a combined treatment process"mixed acidification-Fenton -like-biotreatment" ac-cording to the highly alkaline of cotton pulp black liquor and the extreme acidity of saponin wastewater. The process parameters of different reaction stages were optimized. The results showed that mixed acidification (pH=2.5) not only saved the costs of acid and alkali when the two kinds of wastewater were neutralized separately, but also had synergistic effect on the removal of CODcr. In Fenton-like reaction, CODcrremoval rate was improved about 50% using the residue from warm stick replacing i...