In order to realize the signed addition operation with the spiking neural membrane system, it is necessary to solve the problem of complement representation of signed integers. In this paper, a spiking neural membrane system is designed for symbolic integer complement. Firstly, a spiking neural membrane system is designed to convert the negative integer code into complement code. Secondly, a spiking neural membrane system is designed to separate negative integers from non-negative integers. Finally, on the basis of the spiking neural membrane system with the separation of negative integer and ...