On the basis of single factor experiment,the ultrasonic power,extraction time,extraction temperature,ratio of material to liquid were used as independent variables,and the extraction rate was used as response value.The results showed that the extraction rate of barley lees polyphenols was 4.30 mg/g when the ultrasonic power was 280 W,the extraction temperature was 61℃,the extraction time was 30 min,and the ratio of material to liquid was 1∶34.The actual extraction rate of barley lees polyphenols was 4.28 mg/g measured by the validation test,w...