期刊论文

中文

武汉轻工大学学报

2095-7386

2024

43

04

12-22

10.3969/j.issn.2095-7386.2024.04.002

国家重点研发计划项目(编号：SQ2018YFC200044)；

本校为第一机构

本研究旨在探讨复合膳食纤维对糖尿病小鼠血糖血脂的调节作用，以及其对短链脂肪酸及肠道菌群的影响。选取SPF级C57BL/6J小鼠，空白组喂养基础饲料，其余小鼠连续8周喂养高糖高脂饲料后，腹腔注射链脲佐菌素(streptozotocin, STZ)溶液，建立糖尿病小鼠模型。造模成功后的小鼠随机分为模型对照组、复合膳食纤维低、中、高剂量组。空白组继续喂养基础饲料，模型对照组喂养高糖高脂饲料，复合膳食纤维低、中、高剂量组分别用含2.5%、5.0%、7.5%复合膳食纤维的高糖高脂饲料喂养8周后，模型对照组小鼠改用基础饲料喂养，复合膳食纤维低、中、高剂量组改用含2.5%、5.0%、7.5%复合膳食纤维的基础饲料喂...

This study aimed to investigate the regulatory effects of complex dietary fiber on blood glucose,blood lipids,short-chain fatty acids(SCFAs),and gut microbiota in diabetic mice.SPF-grade C57BL/6J mice were selected,with the control group fed a basal diet while the remaining mice were fed a high-sugar,high-fat diet for 8 weeks followed by intraperitoneal injection of streptozotocin(STZ)solution to induce di-abetes.The diabetic mice were randomly divided into model control group,low,medium,and high-dose complex dietary fiber groups.The control gr...