DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients

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成果类型：

期刊论文

作者：

Chen, Can;Kang, Dandan;Chen, Zhenzhen;Shi, Pengfei;Li, Yun;...

通讯作者：

Qian, SX;Li, Y

作者机构：

[Qian, Shenxian; Chen, Zhenzhen; Chen, Can; Shi, Pengfei; Qian, SX] Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Hematol, Hangzhou, Peoples R China.

[Qian, Shenxian; Chen, Can; Kang, Dandan; Qian, SX] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China.

[Li, Yun; Li, Y] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Team Neonatal & Infant Dev Hlth & Nutr NDHN, Wuhan, Peoples R China.

[Li, Yun; Li, Y] Kindstar Global Precis Med Inst, Wuhan, Peoples R China.

通讯机构：

[Li, Y ; Qian, SX ] W

Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Hematol, Hangzhou, Peoples R China.

Zhejiang Univ, Sch Med, Hangzhou, Peoples R China.

Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Team Neonatal & Infant Dev Hlth & Nutr NDHN, Wuhan, Peoples R China.

Kindstar Global Precis Med Inst, Wuhan, Peoples R China.

语种：

英文

关键词：

Biomarker;CD8 + T cells;DLBCL;DLD;KDM1A

期刊：

Apoptosis

ISSN：

1360-8185

年：

2024

页码：

1-13

DOI：

10.1007/s10495-024-01959-0

基金类别：

This study was funded by Hangzhou science and technology Major Project with Grant Number: 202004A15, Hangzhou Medical health science and technology Major Project with Grant Number: Z20210039 and Zhejiang Province Traditional Chinese medicine science and technology project with Grant Number: 2023ZR122.

机构署名：

本校为通讯机构

院系归属：

生命科学与技术学院

摘要：

Since the discovery of copper induces cell death(cuprotosis) in 2022, it has been one of the biggest research hotspots. cuprotosis related genes (CRGs) has been demonstrated to be a potential therapeutic target for cancer, however, the molecular mechanism of CRGs in coronavirus disease 2019 (COVID-19) infected in DLBCL patients has not been reported yet. Therefore, our research objective is first to elucidate the mechanism and role of CRGs in COVID-19. Secondly, we conducted univariate and multivariate analysis and machine learning to screen fo...

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DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients

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