Acknowledgements This work was finally supported by the Key R&D Projects in Hubei Province, China (2021BCA113), the Open Project of the Technology Innovation Center for Exploitation of Marine Biological Resources, MNR ( TICMBR202201 ), and the Innovation Base for Introducing Talents of Discipline of Hubei Province ( 2019BJH021 ). WP and YZ also acknowledge the support from the State Key Laboratory of Biocatalysis and Enzyme Engineering . Authors’ contributions WP, YZ, JY, and ZC designed the research; YZ, SW, YD, PH, QX, JL and LL