Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer\'s disease - 成果

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Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jiang, Yu-Qing;Wang, Xiu-Li;Cao, Xue-Hong;Ye, Zeng-You;Li, Li*;...

通讯作者：

Li, Li

作者机构：

[Jiang, Yu-Qing; Wang, Xiu-Li] Hebei Med Univ, Hosp 3, Shijiazhuang 050051, Peoples R China.

[Cao, Xue-Hong] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Hubei, Peoples R China.

[Li, Li; Cao, Xue-Hong] Baylor Coll Med, Houston, TX 77030 USA.

[Ye, Zeng-You] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA.

[Li, Li] Dalian Med Univ, Dalian 116044, Liaoning, Peoples R China.

通讯机构：

[Li, Li] B

Baylor Coll Med, Houston, TX 77030 USA.

语种：

英文

关键词：

Alzheimer's disease;HSF1;HSP;Lentivirus vector;Purkinje cell

期刊：

Brain Research

ISSN：

0006-8993

年：

2013

卷：

1519

页码：

105-111

DOI：

10.1016/j.brainres.2013.04.059

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Alzheimer's disease (AD) is one of the most debilitating neurodegenerative nerve diseases, seriously affecting one's ability to carry out daily activities. AD is both progressive and incurable, but molecular studies have begun to shed light on the mechanisms that underlie it. Immunochemical staining showed that cell bodies of Purkinje cells in the cerebellum were significantly reduced in AD rats compared with normal rats. Heat shock protein 70 (HSP70) was found to prevent polyglutamine aggregation in Huntington's disease and spinocerebellar ataxias (SCAs) and to relieve symptoms in SCAs and Pa...

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Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

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