Anemoside B4 attenuates necrotic enteritis of laying hens induced by Clostridium perfringens via inhibiting NF-κB and PI3K/Akt/mTOR signalling pathways

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成果类型：

期刊论文

作者：

Tian, Xinyue;Li, Jingyang;Liu, Siyu;Dong, Qiaoli;Fu, Yunjian;...

通讯作者：

Guo, Ling;Fu, Shulin;Qiu, YS

作者机构：

[Dong, Qiaoli; Fu, Shulin; Qiu, Yinsheng; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Liu, Jin; Lu, Qirong; Sun, Yamin; Tian, Xinyue; Liu, Siyu; Li, Jingyang; Guo, Ling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Dong, Qiaoli; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Liu, Jin; Qiu, Yinsheng; Lu, Qirong; Sun, Yamin; Tian, Xinyue; Liu, Siyu; Li, Jingyang; Fu, Shulin; Guo, Ling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

通讯机构：

[Fu, SL; Qiu, YS ; Guo, L] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Anemoside B4;Clostridium perfringens;NF-κB;Necrotic enteritis;PI3K/Akt/mTOR;Tight junctions

期刊：

Heliyon

ISSN：

2405-8440

年：

2024

卷：

期：

页码：

e33161

DOI：

10.1016/j.heliyon.2024.e33161

基金类别：

Key Research and Development Plan of Hubei Province, China [2023BBB069]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Poultry necrotic enteritis is an important enteric disease which might be controlled by antibiotics. However, with the excessive use of antibiotics, the phenomenon of drug resistance of Clostridium perfringens is becoming increasingly prominent. Anemoside B4 exhibits important antiinflammatory, antioxidant and immunomodulatory effects. This study was performed to estimate the effect of Anemoside B4 on chicken necrotic enteritis induced by C. perfringens in vivo and in vitro. . In the in vivo experiment we investigated the efficacy of Anemoside B4 on the growth curve, biofilm formation, haemoly...

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Anemoside B4 attenuates necrotic enteritis of laying hens induced by Clostridium perfringens via inhibiting NF-κB and PI3K/Akt/mTOR signalling pathways

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