Quantitative lipidomics profiling of skin surface lipids and skin barrier function evaluation in patients with acne vulgaris

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成果类型：

期刊论文

作者：

Cheng, Yahong;Sun, Qingmiao;Gao, Jiefang;Liu, Qin;Tian, Hui;...

通讯作者：

Tian, H;Qiao, JJ;Ding, H;Chen, HJ

作者机构：

[Tian, Hui; Cheng, Yahong] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Hubei, Peoples R China.

[Qiao, JJ; Qiao, Jianjun; Sun, Qingmiao] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Dermatol, Hangzhou 310012, Zhejiang, Peoples R China.

[Ding, Hong; Gao, Jiefang; Ding, H] Wuhan Univ, Sch Pharmaceut Sci, Wuhan, Hubei, Peoples R China.

[Liu, Qin] Wuhan Univ, Zhongnan Hosp, Dept Dermatol, Wuhan, Hubei, Peoples R China.

[Chen, Haijiang] Zhejiang Univ, Ningbo Hosp 1, Dept Dermatol, Ningbo 315000, Zhejiang, Peoples R China.

通讯机构：

[Qiao, JJ ; Chen, HJ ] Z

[Tian, H ; Ding, H ] W

Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan 430023, Hubei, Peoples R China.

Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Dermatol, Hangzhou 310012, Zhejiang, Peoples R China.

Wuhan Univ, Sch Pharmaceut Sci, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

Skin surface lipids;Acne;Skin barrier function;LPC;PG

期刊：

ARCHIVES OF DERMATOLOGICAL RESEARCH

ISSN：

0340-3696

年：

2025

卷：

317

期：

页码：

1-12

DOI：

10.1007/s00403-025-03840-9

基金类别：

This work was supported by Wuhan Worldner United Pharmaceutical Co. Ltd., Wuhan, Hubei, China. Author Hong Ding has received research support from Minimalist Bioscience Wuhan Co. Ltd., Wuhan, Hubei, China.

机构署名：

本校为第一且通讯机构

院系归属：

医学与健康学院

摘要：

Sebum composition may be more important than amount for acne lesions, and current research on skin surface lipids (SSLs) focuses on determining their relative content. The objective of this study was to analyze the changes in the absolute content of SSLs in acne patients and their relationship with skin barrier function. To evaluate skin barrier function, transepidermal water loss (TEWL), skin moisture, sebum content, skin elasticity, and whiteness were measured, while SSL changes were investigated using LC-MS/MS. The results indicated that adult acne patients have reduced skin barrier functio...

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Quantitative lipidomics profiling of skin surface lipids and skin barrier function evaluation in patients with acne vulgaris

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