baicalin;antiinfective agent;baicalin;flavonoid;animal experiment;area under the curve;Article;drug absorption;drug bioavailability;drug blood level;drug clearance;drug distribution;drug elimination;drug half life;female;male;nonhuman;pharmacokinetics;piglet;plasma concentration-time curve;priority journal;animal;blood;half life time;intramuscular drug administration;intravenous drug administration;pig;Animals;Anti-Infective Agents;Area Under Curve;Flavonoids;Half-Life;Injections, Intramuscular;Injections, Intravenous;Swine
期刊：
Journal of Veterinary Pharmacology and Therapeutics
This study was supported by National Key R&D Program of China (Grant No. 2016YFD0501307).
机构署名：
本校为第一且通讯机构
院系归属：
动物科学与营养工程学院
摘要：
The purpose of this study was to determine the pharmacokinetics of baicalin after intravenous and intramuscular administration of sodium baicalin at 50 mg/kg to piglets. Plasma baicalin levels were determined by high-performance liquid chromatography. The plasma concentration-time data of baicalin for both administration routes were best described by two-compartmental open model. The area under the plasma concentration-time curve and the elimination half-lives were 77.47 +/- 6.14 mu g/ml x h and 1.73 +/- 0.16 hr for intravenous and 64.85 +/- 5.67 mu g/ml x h and 2.42 +/- 0.15 hr for intramuscu...
