EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway

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成果类型：

期刊论文

作者：

Xiao, Kan;Liu, Congcong;Qin, Qin;Zhang, Yang;Wang, Xiuying;...

通讯作者：

Liu, Yulan

作者机构：

[Liu, Congcong; Zhang, Yang; Zhang, Jing; Hu, Chien-An Andy; Qin, Qin; Liu, Yulan; Xiao, Kan; Wang, Xiuying] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Xuefunan Rd, Wuhan 430023, Hubei, Peoples R China.

[Odle, Jack; Lin, Xi] North Carolina State Univ, Lab Dev Nutr, Dept Anim Sci, Raleigh, NC USA.

[Hu, Chien-An Andy] Univ New Mexico, Sch Med, Dept Biochem & Mol Biol, Albuquerque, NM 87131 USA.

通讯机构：

[Liu, Yulan] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Xuefunan Rd, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

barrier function;cell injury;deoxynivalenol;necroptosis signaling pathway;n-3 PUFA

期刊：

FASEB JOURNAL

ISSN：

0892-6638

年：

2020

卷：

期：

页码：

2483-2496

DOI：

10.1096/fj.201902298R

基金类别：

National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China [31772615]; Wuhan Science and Technology Burea [2018020401011304]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Deoxynivalenol (DON) is one of the most common mycotoxins that contaminates food or feed and cause intestinal damage. Long-chain n-3 polyunsaturated fatty acids (PUFA) such as EPA and DHA exert beneficial effects on intestinal integrity in animal models and clinical trials. Necroptosis signaling pathway plays a critical role in intestinal cell injury. This study tested the hypothesis that EPA and DHA could alleviate DON-induced injury to intestinal porcine epithelial cells through modulation of the necroptosis signaling pathway. Intestinal porcine epithelial cell 1 (IPEC-1) cells were cultured...

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EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway

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