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Flaxseed Oil Attenuates Intestinal Damage by Regulating Ferroptosis Signaling Pathway Following LPS Challenge in Piglets

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成果类型:
期刊论文
作者:
Guo, Junjie;Chen, Xiaoqian;Zhou, Mohan;Yu, Xintian;Zhu, Huiling;...
通讯作者:
Liu, YL
作者机构:
[Liu, Yulan; Xiao, Kan; Guo, Junjie; Zhou, Mohan; Liu, YL; Chen, Xiaoqian; Yu, Xintian; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.
[Chen, Guoshun; Guo, Junjie] Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou, Peoples R China.
通讯机构:
[Liu, YL ] W
Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.
语种:
英文
关键词:
ferroptosis;flaxseed oil;intestinal damage;lipopolysaccharide;piglet
期刊:
MOLECULAR NUTRITION & FOOD RESEARCH
ISSN:
1613-4125
年:
2024
卷:
68
期:
17
基金类别:
National Natural Science Foundation of China [U22A20517]; Wuhan Science and Technology Bureau [2022020801020394]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
ScopeFerroptosis has been demonstrated to play an important role in various tissue injuries and diseases. Flaxseed oil (FO) has been proven to have benefits for intestinal health. This study aims to explore whether FO relieved lipopolysaccharide (LPS)-induced intestinal injury through modulating ferroptosis signaling pathway.Methods and resultsA total of 120 weaned piglets are fed diets with 3% soybean oil (SO) or 3% FO for 4 weeks. At the end of the trial, 24 piglets selected from two dietary treatment groups are used in a 2 x 2 factorial design with oil treatment (3% SO versus 3% FO) and LPS...

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