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The intervention mechanism of folic acid for benzo(a)pyrene toxic effects in vitro and in vivo

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成果类型:
期刊论文
作者:
Wang, Pengcheng;Chen, Yuwei;Wang, Lei;Wu, Yang;Wang, Lichun;...
通讯作者:
Gong, Zhiyong
作者机构:
[Chen, Yuwei; Wu, Yang; Gong, Zhiyong; Wang, Lei; Wang, Lichun; Wang, Pengcheng] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.
[Wu, Yongning] China Natl Ctr Food Safety Risk Assessment, Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China.
[Gong, Zhiyong] WuHan Polytech Univ Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.
通讯机构:
[Gong, Zhiyong] W
WuHan Polytech Univ Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
benzo(a)pyrene;cell cycle;folic acid;interference effect
期刊:
EUROPEAN JOURNAL OF CANCER PREVENTION
ISSN:
0959-8278
年:
2019
卷:
28
期:
4
页码:
355-364
基金类别:
This project was supported by the National Natural Science Foundation of China (grant no. 21077082). The experiments conducted in this research comply with the current laws of the People’s Republic of China.
机构署名:
本校为第一机构
院系归属:
食品科学与工程学院
摘要:
Folic acid is a necessary micronutrient for normal human growth and development. Benzo(a)pyrene (BaP) is a ubiquitously distributed environmental pollutant and its metabolite, benzo(a)pyrene-diol-epoxide, is known to exert a strong teratogenic and carcinogenic effect on the body’s tissues and cells. The aim of this study was to investigate the mechanism by which folic acid can inhibit the toxic effects of BaP both in vivo and in vitro. We measured changes in 16HBE cell activity affected by the intervention of folic acid on BaP using the cell c...

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