Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer\'s disease - 成果

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Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Zhijun;Li, Xiaoqian;Wang, Zi;Cao, Yingqi;Han, Shuangxue;...

通讯作者：

Liu, Q;Cai, J

作者机构：

[Cheng, Shuiyuan; Cai, Jie; He, Zhijun] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

[Li, Xiaoqian; Wang, Zi; Han, Shuangxue; Cao, Yingqi; He, Zhijun; Li, Nan; Liu, Qiong] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518055, Guangdong, Peoples R China.

[Li, Nan; Liu, Qiong] Shenzhen Fundamental Res Inst, Shenzhen Hong Kong Inst Brain Sci, Shenzhen 518055, Peoples R China.

[Liu, Qiong] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518055, Peoples R China.

[Cai, Jie] Wuhan Polytech Univ, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Liu, Q ] S

[Cai, J ] W

Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518055, Peoples R China.

Wuhan Polytech Univ, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Luteolin Alzheimer's disease (AD);beta-amyloid (A beta);Mitochondrial impairments;Apoptosis;Peroxisome proliferator-activated receptor gamma (PPAR gamma)

期刊：

Redox Biology

ISSN：

2213-2317

年：

2023

卷：

页码：

102848

DOI：

10.1016/j.redox.2023.102848

基金类别：

Shenzhen Science and Technology Innovation Commission [JCYJ20200109110001818]; Shenzhen-Hong Kong Institute of brain Science-Shenzhen Fundamental Research institutions [2023SHIBS0003]

机构署名：

本校为第一且通讯机构

院系归属：

硒科学与工程现代产业学院

摘要：

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the deposition of beta-amyloid (A beta) peptides and dysfunction of mitochondrion, which result in neuronal apoptosis and ultimately cognitive impairment. Inhibiting A beta generation and repairing mitochondrial damage are prominent strategies in AD therapeutic treatment. Luteolin, a flavonoid compound, exhibits anti-inflammatory neuroprotective properties in AD mice. However, it is still unclear whether luteolin has any effect on A beta pathology and mitochondrial dysfunction. In this study, the beneficial e...

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Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease

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