Protein corona of airborne nanoscale PM2.5 induces aberrant proliferation of human lung fibroblasts based on a 3D organotypic culture

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成果类型：

期刊论文

作者：

Li, Yan;Wang, Pengcheng;Hu, Chuanlin;Wang, Kun;Chang, Qing;...

通讯作者：

Gong, Zhiyong;Wu, Yang

作者机构：

[Li, Yan; Wang, Pengcheng] Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.

[Wu, Yang; Gong, Zhiyong; Wu, Y] Wuhan Polytech Univ, Coll Food Sci & Engn, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.

[Li, Yan; Mak, Michael] Yale Univ, Sch Engn & Appl Sci, Dept Biomed Engn, New Haven, CT 06520 USA.

[Wang, Kun] NYU, Dept Populat Hlth, Div Biostat, 550 1st Ave, New York, NY 10016 USA.

[Chang, Qing] Hong Kong Univ Sci & Technol, Dept Chem & Biomol Engn, Kowloon, Hong Kong, Peoples R China.

通讯机构：

[Gong, ZY; Wu, Y] W

Wuhan Polytech Univ, Coll Food Sci & Engn, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2018

卷：

期：

页码：

1939

DOI：

10.1038/s41598-018-20445-7

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21607117]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

生命科学与技术学院

摘要：

AbstractExposure to PM2.5 has become one of the most important factors affecting public health in the world. Both clinical and research studies have suggested that PM2.5 inhalation is associated with impaired lung function. In this study, material characterization identified the existence of nanoscale particulate matter (NPM) in airborne PM2.5 samples. When coming into contact with protein-rich fluids, the NPM becomes covered by a protein layer that forms a “protein corona”. Based on a 3D organotypic cell culture, the protein corona was shown...

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Protein corona of airborne nanoscale PM2.5 induces aberrant proliferation of human lung fibroblasts based on a 3D organotypic culture

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