期刊论文

中文

食品工业科技

1002-0306

2019

40

16

248-254

10.13386/j.issn1002-0306.2019.16.042

本校为第一机构

目的:研究两种植物甾醇纳米粒对高血脂小鼠的降胆固醇效果。方法:建立高血脂小鼠模型,随后将小鼠分为8组:正常组、高脂模型组、阳性对照组、植物甾醇（PS）组、植物甾醇纳米粒（PNP）组、空白纳米粒（NP）组、壳聚糖修饰植物甾醇纳米粒（CS-PNP）组、空白壳聚糖修饰纳米粒（CS-NP）组,连续干预4周。测定小鼠体重、采食量变化,脏器指数、血清指标、肝脂含量以及粪便中甾醇含量,并进行肝脏切片观察。结果:各给药组对小鼠采食量及体重无显著影响（p> 0.05）; PNP和CS-PNP组小鼠肝系数较高脂组显著降低（p

Objective: To investigate the cholesterol-lowering effect of two types of phytosterol nanoparticles on hyperlipidemic mice.Methods: The mice were divided into 8 groups randomly after the successful establishment of the high-fat diet( HFD)-induced hyperlipidemia model: normal group,hyperlipidemic model group,positive control group,phytosterol( PS) group,phytosterol nanoparticles( PNP) group,nanoparticles without phytosterol( NP) group,chitosan-modified phytosterol nanoparticles( CS-PNP) group,and chitosan-modified nanoparticles without phytosterol( CS-NP) group. The intervention of different sa...