Gaussian clustering and quantification of the sperm chromatin dispersion test using convolutional neural networks

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成果类型：

期刊论文

作者：

Yang, Zheng;Zhang, Lei;Fan, Heng;Yan, Bei;Mu, Yaoqin;...

通讯作者：

Xiao, XJ;Li, LJ

作者机构：

[Yang, Zheng; Xiao, Xianjin; Mu, Yaoqin; Xiao, XJ; Yan, Bei; Zhang, Lei; Fan, Heng] Huazhong Univ Sci & Technol, Inst Reprod Hlth, Tongji Med Coll, Wuhan 430030, Peoples R China.

[Pei, Chengbin; Yan, Bei; Zhou, Yue] Ningxia Med Univ, Gen Hosp, Inst Med Sci, Ningxia Human Sperm Bank, Yinchuan 750004, Peoples R China.

[Li, Longjie] Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan 430023, Peoples R China.

[Xiao, Xianjin; Xiao, XJ] Hunan Normal Univ, Changsha Hosp Maternal & Child Hlth Care, Hunan Prov Key Lab Reg Hereditary Birth Defects Pr, Changsha, Peoples R China.

通讯机构：

[Li, LJ ] W

[Xiao, XJ ] H

Huazhong Univ Sci & Technol, Inst Reprod Hlth, Tongji Med Coll, Wuhan 430030, Peoples R China.

Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan 430023, Peoples R China.

Hunan Normal Univ, Changsha Hosp Maternal & Child Hlth Care, Hunan Prov Key Lab Reg Hereditary Birth Defects Pr, Changsha, Peoples R China.

语种：

英文

期刊：

ANALYST

ISSN：

0003-2654

年：

2024

卷：

149

期：

页码：

366-375

DOI：

10.1039/d3an01616a

基金类别：

Hunan Province Assisted Reproduction and Regenerative Medicine Clinical Demonstration Center [2020SK4019]; Tongji hospital, Huazhong University of Science and Technology

机构署名：

本校为通讯机构

摘要：

Sperm DNA fragmentation is a sign of sperm nuclear damage. The sperm chromatin dispersion (SCD) test is a reliable and economical method for the evaluation of DNA fragmentation. However, the cut-off value for differentiation of DNA fragmented sperms is fixed at 1/3 with limited statistical justification, making the SCD test a semi-quantitative method that gives user-dependent results. We construct a collection of deep neural networks to automate the evaluation of bright-field images for SCD tests. The model can detect valid sperm nuclei and the...

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Gaussian clustering and quantification of the sperm chromatin dispersion test using convolutional neural networks

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