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Identification and Validation of Aging-Related Genes in Idiopathic Pulmonary Fibrosis

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成果类型:
期刊论文
作者:
He, Jie;Li, Xiaoyan
通讯作者:
He, J
作者机构:
[He, Jie; He, J; Li, Xiaoyan] Chengdu Med Coll, Clin Med Coll, Chengdu, Peoples R China.
[He, Jie; He, J] Chengdu Med Coll, Dept Resp & Crit Care Med, Affiliated Hosp 1, Chengdu, Peoples R China.
[Li, Xiaoyan] Chengdu Med Coll, Dept Endocrinol, Affiliated Hosp 1, Chengdu, Peoples R China.
通讯机构:
[He, J ] C
Chengdu Med Coll, Clin Med Coll, Chengdu, Peoples R China.
Chengdu Med Coll, Dept Resp & Crit Care Med, Affiliated Hosp 1, Chengdu, Peoples R China.
语种:
英文
关键词:
aging;IPF;bioinformatics analysis;gene expression omnibus dataset;gene
期刊:
Frontiers in Genetics
ISSN:
1664-8021
年:
2022
卷:
13
基金类别:
Sichuan Medical Association Research Project [20210205020018]
机构署名:
本校为第一且通讯机构
摘要:
Aging plays a significant role in the occurrence and development of idiopathic pulmonary fibrosis (IPF). In this study, we aimed to identify and verify potential aging-associated genes involved in IPF using bioinformatic analysis. The mRNA expression profile dataset GSE150910 available in the Gene Expression Omnibus (GEO) database and R software were used to identify the differentially expressed aging-related genes involved in IPF. Hub gene expression was validated by other GEO datasets. Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichmen...

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