Achieving apoptosis/cuproptosis co-activated synergistic anti-tumor therapy by charges transport engineering

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成果类型：

期刊论文

作者：

Hou, Hua-Ying;Chu, Xu;Duan, Meng-Die;Zhang, Yu-Juan;Chen, Hong-Li;...

通讯作者：

Liu, Yi;Li, SL

作者机构：

[Liu, Yi; Sun, Yue; Li, Shu-Lan; Hou, Hua-Ying] Tiangong Univ, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China.

[Liu, Yi; Sun, Yue; Li, Shu-Lan; Hou, Hua-Ying] Tiangong Univ, Sch Elect & Informat Engn, Key Lab Hollow Fiber Membrane Mat & Membrane Proc, MOE, Tianjin 300387, Peoples R China.

[Liu, Yi; Sun, Yue; Li, Shu-Lan; Hou, Hua-Ying] Tiangong Univ, Sch Chem, Tianjin 300387, Peoples R China.

[Duan, Meng-Die; Zhang, Yu-Juan; Chu, Xu] Tiangong Univ, Sch Mat Engn & Technol, Tianjin 300387, Peoples R China.

[Duan, Meng-Die; Zhang, Yu-Juan; Chu, Xu] Tiangong Univ, Sch Chem Engn & Technol, Tianjin 300387, Peoples R China.

通讯机构：

[Liu, Y; Li, SL ] T

Tiangong Univ, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China.

Tiangong Univ, Sch Elect & Informat Engn, Key Lab Hollow Fiber Membrane Mat & Membrane Proc, MOE, Tianjin 300387, Peoples R China.

Tiangong Univ, Sch Chem, Tianjin 300387, Peoples R China.

语种：

英文

关键词：

S -Scheme heterojunction;Cuproptosis;Nanocatalytic therapy;Chemodynamic therapy;Apoptosis

期刊：

Nano Today

ISSN：

1748-0132

年：

2025

卷：

页码：

102689

DOI：

10.1016/j.nantod.2025.102689

基金类别：

CRediT authorship contribution statement Hua-Ying Hou: Data curation, Investigation, Writing – original draft. Xu Chu: Data curation, Formal analysis, Validation. Meng-Die Duan: Formal analysis, Validation. Yu-Juan Zhang: Data curation, Investigation, Validation. Hong-Li Chen: Investigation. Yue Sun: acquisition, Supervision, Writing – review & Editing. Yi Liu: acquisition, Supervision, Validation, Writing –review & editing. Shu-Lan Li: Conceptualization, acquisition, Methodology, Supervision, Writing – review

机构署名：

本校为通讯机构

院系归属：

化学与环境工程学院

摘要：

Nanocatalysts show great promise in nanomedicine due to their unique catalytic activities. However, the rapid recombination of excited electrons and holes leads to low efficacy of nanocatalytic therapy. Herein, ultrasmall S-Scheme heterojunction MoC/CuFeO x nanoparticles (MCFO NPs) with specific charge transport route are rationally designed and engineered for efficient apoptosis/cuproptosis co-activated nanocatalytic therapy. Thermal analysis revealed two steps of S-Scheme heterojunction formation: adsorption and internal structure change. In this structure, the staggered energy levels and ba...

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Achieving apoptosis/cuproptosis co-activated synergistic anti-tumor therapy by charges transport engineering

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