Self-assembly of selenium-loaded octenyl succinic anhydride-modified starch nanomicelles for treating inflammation-related brain diseases

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成果类型：

期刊论文

作者：

He, Zhijun;Li, Xiaoqian;Yang, Zhaoxing;Liu, Xiaoqing;Xie, Fang;...

通讯作者：

Liu, Q;Liu, Qiong;Cai, J

作者机构：

[Yang, Zhaoxing; Xie, Fang; Lv, Xuqin; Cheng, Shuiyuan; Cai, Jie; He, Zhijun] Wuhan Polytech Univ, Natl R&D Ctr Se Rich Agr Prod Proc, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

[Li, Xiaoqian; He, Zhijun; Liu, Qiong; Ni, Jiazuan] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518055, Guangdong, Peoples R China.

[Cai, Jie; Liu, Xiaoqing] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Hubei Key Lab Proc & Transformat Agr Prod, Minist Educ, Wuhan 430023, Peoples R China.

[Liu, Qiong] Shenzhen Hong Kong Inst Brain Sci, Shenzhen Fundamental Res Inst, Shenzhen 518055, Peoples R China.

[Liu, Xiaoqing; Liu, Qiong] Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518055, Peoples R China.

通讯机构：

[Liu, Q ] S

[Cai, J ; Liu, Q] W

Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518055, Peoples R China.

Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

FA-OSAS-SeNPs;Lipopolysaccharide;Neuroinflammation;Endoplasmic reticulum stress

期刊：

Chemical Engineering Journal

ISSN：

1385-8947

年：

2024

卷：

483

页码：

149168

DOI：

10.1016/j.cej.2024.149168

基金类别：

Science and Technology Research Project of the Hubei Provincial Department of Education [D20211605]; Shenzhen Science and Technology Innovation Commission [JCYJ20200109110001818]; Shenzhen-Hong Kong Institute of brain Science-Shenzhen Fundamental Research institutions [2023SHIBS0003]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

硒科学与工程现代产业学院

摘要：

Neuroinflammation, caused by abnormal activation of glial cells, plays an important role in nerve injury, which can lead to cognitive impairment. Consequently, regulating glial cell activation and subsequent generation of inflammatory mediators is valuable for the treatment of neuroinflammation-based brain diseases. Selenium (Se) and folic acid (FA) are two key nutritional supplements that have bioactivities associated with regulating neuroinflammatory responses, resisting oxidative stress, and preventing neuronal apoptosis in vivo. Based on th...

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Self-assembly of selenium-loaded octenyl succinic anhydride-modified starch nanomicelles for treating inflammation-related brain diseases

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