期刊论文

Hou, Yongqing

英文

Frontiers in Bioscience-Landmark

2768-6701

2018

23

11

2166-2176

10.2741/4697

Dan Yi and Wenkai Liu contributed equally to this work and should be considered as co-first authors. The animal use protocol for this research was approved by the Institutional Animal Care and Use Committee at Wuhan Polytechnic University. Our work was jointly supported by National Key R&D Program of China (2016YFD0501210, 2017YFD0500505), the Program of National Agricultural Research Outstanding Talents of China (2015), Hubei Provincial Technology and Innovation Program (2016ABA121, 2017AHB062), Natural Science Foundation of Hubei Province (2016CFA070), the Hubei Hundred Talent Program, Agriculture and Food Research Initiative Competitive

本校为第一且通讯机构

A useful animal model of intestinal injury is pivotal for studying its pathogenesis and developing nutritional interventions (e.g., amino acid supplementation). Here, we propose the use of indomethacin (IDMT) to induce intestinal inflammation in neonatal pigs. Fourteen-day-old piglets fed a milk replacer diet receive intraperitoneal administration of IDMT (5 mg/kg body weight) for 3 consecutive days. On day 4, blood and intestinal samples are obtained for physiological and biochemical analyses. IDMT increases blood DAO activity, I-FABP concentr...