Dan Yi and Wenkai Liu contributed equally to this work and should be considered as co-first authors. The animal use protocol for this research was approved by the Institutional Animal Care and Use Committee at Wuhan Polytechnic University. Our work was jointly supported by National Key R&D Program of China (2016YFD0501210, 2017YFD0500505), the Program of National Agricultural Research Outstanding Talents of China (2015), Hubei Provincial Technology and Innovation Program (2016ABA121, 2017AHB062), Natural Science Foundation of Hubei Province (2016CFA070), the Hubei Hundred Talent Program, Agriculture and Food Research Initiative Competitive