Dietary Supplementation with α-Ketoglutarate Activates mTOR Signaling and Enhances Energy Status in Skeletal Muscle of Lipopolysaccharide-Challenged Piglets

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Lei;Yi, Dan;Hou, Yongqing*;Ding, Binying;Li, Kang;...

通讯作者：

Hou, Yongqing;Wu, Guoyao

作者机构：

[Li, Kang; Liu, Yulan; Li, Baocheng; Hou, Yongqing; Wu, GY; Wang, Lei; Wu, Guoyao; Ding, Binying; Yi, Dan; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan, Peoples R China.

[Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.

通讯机构：

[Hou, YQ; Wu, GY] W

[Wu, Guoyao] T

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan, Peoples R China.

Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.

语种：

英文

关键词：

*cell signaling;*gastrocnemius muscle;*inflammation;*lipopolysaccharide;*alpha-ketoglutarate

期刊：

The Journal of Nutrition

ISSN：

0022-3166

年：

2016

卷：

146

期：

页码：

1514-1520

DOI：

10.3945/jn.116.236000

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572416, 31372319, 31402084]; Hubei Provincial Key Project for Scientific and Technical Innovation [2014ABA022]; Hubei Provincial Research and Development Program [2010BB023]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2013CFA097, 2012FFB04805, 2011CDA131]; Hubei Hundred Talent Program; Texas A&M AgriLife Research [H-8200]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Background: Skeletal muscle undergoes rapid loss in response to inflammation. a-Ketoglutarate (AKG) has been reported to enhance muscle growth in piglets, but the underlying mechanisms are largely unknown. Objectives: This study tested the hypothesis that dietary AKG supplementation activates mechanistic target of rapamycin (mTOR) signaling and improves skeletal muscle energy metabolism in lipopolysaccharide (LPS)-challenged piglets. Methods: Forty-eightmale piglets (Duroc × Landrace × Yorkshire)wereweaned at 21 d of age to a corn- and soybea...

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Dietary Supplementation with α-Ketoglutarate Activates mTOR Signaling and Enhances Energy Status in Skeletal Muscle of Lipopolysaccharide-Challenged Piglets

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