Dietary supplementation of branched-chain amino acids increases muscle net amino acid fluxes through elevating their substrate availability and intramuscular catabolism in young pigs

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成果类型：

期刊论文

作者：

Zheng, Liufeng;Zuo, Fangrui;Zhao, Shengjun;He, Pingli;Wei, Hongkui;...

通讯作者：

Peng, Jian

作者机构：

[Zheng, Liufeng; Zuo, Fangrui; Wei, Hongkui; Xiang, Quanhang; Pang, Jiaman; Peng, Jian] Huazhong Agr Univ, Dept Anim Nutr & Feed Sci, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China.

[Zhao, Shengjun] Wuhan Polytech Univ, Dept Feed Sci, Wuhan 430070, Peoples R China.

[He, Pingli] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China.

[Wei, Hongkui; Peng, Jian] Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R China.

通讯机构：

[Peng, Jian] H

[Peng, Jian] C

Huazhong Agr Univ, Dept Anim Nutr & Feed Sci, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China.

Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R China.

语种：

英文

关键词：

Branched-chain amino acids;Young pigs;Hindlimb muscle;Net amino acid fluxes;Metabolomic profiling

期刊：

British Journal of Nutrition

ISSN：

0007-1145

年：

2017

卷：

117

期：

页码：

911-922

DOI：

10.1017/S0007114517000757

基金类别：

National Basic Research Program of China (973 Program)National Basic Research Program of China [2013CB127305]; Key Technology Research and Development Program of Hubei Province [2014ABB014, 2014ABC012]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Branched-chain amino acids (BCAA) have been clearly demonstrated to have anabolic effects on muscle protein synthesis. However, little is known about their roles in the regulation of net AA fluxes across skeletal muscle in vivo. This study was aimed to investigate the effect and related mechanisms of dietary supplementation of BCAA on muscle net amino acid (AA) fluxes using the hindlimb flux model. In all fourteen 4-week-old barrows were fed reduced-protein diets with or without supplemental BCAA for 28 d. Pigs were implanted with carotid arter...

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Dietary supplementation of branched-chain amino acids increases muscle net amino acid fluxes through elevating their substrate availability and intramuscular catabolism in young pigs

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