Snakehead vesiculovirus (SHVV) leader RNA interacts with host antiviral factors RPS8 and L13a and promotes virus replication

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成果类型：

期刊论文

作者：

Ji, Yan;Cheng, Rui;Zhou, Xuan;Zhang, Jiaqi;Liu, Xiaodan;...

通讯作者：

Zhang, Chi

作者机构：

[Ji, Yan; Zhang, Jiaqi] Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, 430023, China

[Cheng, Rui] Key Laboratory of Ecological Impacts of Hydraulic-Projects and Restoration of Aquatic Ecosystem of Ministry of Water Resources, Institute of Hydroecology, MWR &CAS, Wuhan, 430070, China

[Zhou, Xuan] Technology Center of Wuhan Customs, Wuhan, 430050, China

[Liu, Xiaodan] College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China

[Sheng, Suhong] Huzhou Shengjiang Fishery Co., LTD, Huzhou, 313018, China

通讯机构：

[Zhang, Chi] H

Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, 430023, China. Electronic address:

语种：

英文

关键词：

L13a;Leader RNA;RPS8;Replication;Snakehead vesiculovirus

期刊：

Fish & Shellfish Immunology

ISSN：

1050-4648

年：

2024

卷：

148

页码：

109466

DOI：

10.1016/j.fsi.2024.109466

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

To evade host antiviral response, viruses have evolved to take advantage of their noncoding RNAs (ncRNAs). Snakehead vesiculovirus (SHVV), a newly isolated fish rhabdovirus from diseased hybrid snakehead, has caused high mortality to the cultured snakehead fish during the past years in China. However, little is known about the mechanisms of its pathogenicity. Our study revealed that overexpression of the 30-nt leader RNA promoted SHVV replication. RNA-protein binding investigation revealed that SHVV leader RNA could interact with host 40S ribosomal protein S8 (RPS8) and 60S ribosomal protein L...

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Snakehead vesiculovirus (SHVV) leader RNA interacts with host antiviral factors RPS8 and L13a and promotes virus replication

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