Snakehead vesiculovirus (SHVV) leader RNA interacts with host antiviral factors RPS8 and L13a and promotes virus replication

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成果类型：

期刊论文

作者：

Ji, Yan;Cheng, Rui;Zhou, Xuan;Zhang, Jiaqi;Liu, Xiaodan;...

通讯作者：

Zhang, C

作者机构：

[Ji, Yan; Zhang, Chi; Zhang, Jiaqi] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Cheng, Rui] MWR &CAS, Minist Water Resources, Inst Hydroecol, Key Lab Ecol Impacts Hydraul Projects & Restorat A, Wuhan 430070, Peoples R China.

[Zhou, Xuan] Technol Ctr Wuhan Customs, Wuhan 430050, Peoples R China.

[Liu, Xiaodan] Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China.

[Sheng, Suhong] Huzhou Shengjiang Fishery Co LTD, Huzhou 313018, Peoples R China.

通讯机构：

[Zhang, C ] W

Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

L13a;Leader RNA;RPS8;Replication;Snakehead vesiculovirus

期刊：

Fish & Shellfish Immunology

ISSN：

1050-4648

年：

2024

卷：

148

页码：

109466

DOI：

10.1016/j.fsi.2024.109466

基金类别：

National Natural Science Foundation of China [32303068]; Scientific Research Project of Wuhan Customs [2023WK011]; Research and Innovation Initiatives of WHPU [2023Y36]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

To evade host antiviral response, viruses have evolved to take advantage of their noncoding RNAs (ncRNAs). Snakehead vesiculovirus (SHVV), a newly isolated fish rhabdovirus from diseased hybrid snakehead, has caused high mortality to the cultured snakehead fish during the past years in China. However, little is known about the mechanisms of its pathogenicity. Our study revealed that overexpression of the 30-nt leader RNA promoted SHVV replication. RNA-protein binding investigation revealed that SHVV leader RNA could interact with host 40S ribosomal protein S8 (RPS8) and 60S ribosomal protein L...

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Snakehead vesiculovirus (SHVV) leader RNA interacts with host antiviral factors RPS8 and L13a and promotes virus replication

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