Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis

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成果类型：

期刊论文

作者：

Lei, Zhixin;Fu, Shulin;Yang, Bing;Liu, Qianying;Ahmed, Saeed;...

通讯作者：

Cao, Jiyue;Qiu, Yinsheng

作者机构：

[Yang, Bing; Ahmed, Saeed; Liu, Qianying; Lei, Zhixin; Xiong, Jincheng; Cao, Jiyue] Huazhong Agr Univ, Coll Vet Med, Vet Pharmacol Lab, Wuhan 430070, Hubei, Peoples R China.

[Yang, Bing; Ahmed, Saeed; Liu, Qianying; Lei, Zhixin; Xiong, Jincheng; Cao, Jiyue] Huazhong Agr Univ, Nat Reference Lab Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Yang, Bing; Ahmed, Saeed; Liu, Qianying; Lei, Zhixin; Xiong, Jincheng; Cao, Jiyue] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Xu, Lei; Qiu, Yinsheng; Fu, Shulin] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Cao, Jiyue] H

[Qiu, Yinsheng] W

Huazhong Agr Univ, Coll Vet Med, Vet Pharmacol Lab, Wuhan 430070, Hubei, Peoples R China.

Huazhong Agr Univ, Nat Reference Lab Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2017

卷：

期：

页码：

7517

DOI：

10.1038/s41598-017-07972-5

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572572]

机构署名：

本校为通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Numerous studies have been conducted to examine the molecular mechanism of Haemophilus parasuis resistance to antibiotic, but rarely to tildipirosin. In the current study, transcriptional profiling was applied to analyse the variation in gene expression of JS0135 and tildipirosin-resistant JS32. The growth curves showed that JS32 had a higher growth rate but fewer bacteria than JS0135. The cell membranes of JS32 and a resistant clinical isolate (HB32) were observed to be smoother than those of JS0135. From the comparative gene expression profile 349 up- and 113 downregulated genes were observe...

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Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis

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