期刊论文

中文

山东医药

1002-266X

2022

62

14

9-13+24

10.3969/j.issn.1002-266X.2022.14.003

本校为第一机构

目的 基于网络药理学和分子对接的方法，探讨香叶木素治疗高尿酸血症肾病（HN）的分子机制。方法 运用中药系统药理学平台（TCMSP）、SwissTargetPrediction数据库、ChEMBL数据库筛选香叶木素的作用靶点基因，借助GeneCards、DisGeNET数据库检索HN疾病靶点基因，运用Venny 2.1在线工具获取香叶木素与HN的共有靶点基因；基于STRING数据库构建共有靶点基因的蛋白质—蛋白质相互作用关系（PPI）网络，通过Cystoscape软件进行可视化分析，拓扑学分析筛选核心靶点基因；借助DAVID数据库对共有靶点基因进行GO功能注释和KEGG通路富集分析。以核心靶点基因编码的蛋白为受体、香叶木素为配体，采用AutoDo...

Objective To explore the potential molecular mechanism of diosmetin in the treatment of hyperuricemic nephropathy(HN)based on network pharmacology and molecular docking.Methods Traditional Chinese medicine system pharmacology database and analysis platform(TCMSP),SwissTargetPrediction database and ChEMBL database were used to screen the action target genes of diosmetin,HN-related target genes were searched with the GeneCards database,DisGeNET database,and the common target genes of diosmetin and HN were obtained by Venny 2.1 online mapping tool...