Network Pharmacology to Unveil the Mechanism of Berberine in the Treatment of Streptococcus suis Meningitis in Humans and Pigs

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成果类型：

期刊论文

作者：

Guo, Pu;Xue, Yunda;Zhang, Dan;Lu, Qirong;Liu, Yu;...

通讯作者：

Qiu, YS;Wang, X

作者机构：

[Liu, Yu; Xiong, Jianglin; Qiu, Yinsheng; Guo, Pu; Ye, Chun; Zhang, Dan; Lu, Qirong; Xue, Yunda; Wu, Zhongyuan; Fu, Shulin] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Liu, Yu; Xiong, Jianglin; Qiu, Yinsheng; Guo, Pu; Ye, Chun; Zhang, Dan; Lu, Qirong; Xue, Yunda; Wu, Zhongyuan; Fu, Shulin] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan Engn & Technol Res Ctr Anim Dis Resistant Nu, Wuhan 430023, Peoples R China.

[Wang, Xu] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Peoples R China.

[Wang, Xu] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Peoples R China.

通讯机构：

[Qiu, YS ] W

[Wang, X ] H

Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan Engn & Technol Res Ctr Anim Dis Resistant Nu, Wuhan 430023, Peoples R China.

Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Peoples R China.

语种：

英文

关键词：

berberine;S. suis;meningitis;anti-inflammatory;anti-oxidative stress;network pharmacology

期刊：

Toxics

ISSN：

2305-6304

年：

2025

卷：

期：

DOI：

10.3390/toxics13020138

基金类别：

Key Research and Development Plan of Hubei Province, China; [2023BBB069]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Streptococcus suis (S. suis) is a major swine pathogen throughout the world as well as an emerging zoonotic agent. Among the symptoms caused by S. suis, including septicemia, pneumonia, endo-carditis, arthritis, and meningitis, the latter is the most overlooked. In the present study, we explored the mechanism of action of berberine against S. suis meningitis by obtaining berberine-related action targets, porcine S. suis meningitis targets, and human S. suis meningitis targets from open databases. We constructed a protein-protein interaction (PPI) network by using the STRING database and employ...

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Network Pharmacology to Unveil the Mechanism of Berberine in the Treatment of Streptococcus suis Meningitis in Humans and Pigs

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