期刊论文

Liu, Yulan

英文

JOURNAL OF NUTRITIONAL BIOCHEMISTRY

0955-2863

2014

25

6

592-599

10.1016/j.jnutbio.2014.01.010

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31372318, 31172222, 30972109]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-10-0158]; National Basic Research Program of ChinaNational Basic Research Program of China [2012CB126305]; Project of Natural Science Foundation of Hubei Province [2013CFA029, 2010CDA050]; Project of International Cooperation of Hubei Province [2011BFA008]

本校为第一且通讯机构

Pro-inflammatory cytokines play a critical role in many models of liver injury. In addition, aspartate (Asp) plays an important role in many biological and physiological processes including liver physiology. We hypothesized that Asp could alleviate lipopolysaccharide (LPS)-induced liver injury. Forty-eight weanling pigs were assigned to four treatments including: (1) non-challenged control; (2) LPS challenged control; (3) LPS+0.5% Asp; (4) LPS+1.0% Asp. After 20-d feeding with control (0% Asp), 0.5% or 1.0% Asp supplemented diets, pigs were injected with saline or LPS. At 4 (early phase) and 2...