Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wei, Wei;Xu, Pan;Li, Li;Mao, Hong;Li, Na;...

通讯作者：

Zhao, S

作者机构：

[Li, Li; Zhao, Shi; Wei, Wei; Li, Na; Mao, Hong] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China.

[Xu, Pan] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Neurol, Wuhan, Peoples R China.

[Wang, Xiao-qing] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Peoples R China.

[Wang, Li] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Nursing, Wuhan, Peoples R China.

[Xu, Zhi-peng] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med,Hubei Key Lab Neurol Disorders, Dept Pathophysiol,Minist Educ,Key Lab Neurol Disor, Wuhan, Peoples R China.

通讯机构：

[Zhao, S ] H

Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China.

语种：

英文

关键词：

Alzheimer’s disease;ApoE gene;glycogen synthase kinase-3β;mild cognitive impairment;type 2 diabetes mellitus

期刊：

FRONTIERS IN ENDOCRINOLOGY

ISSN：

1664-2392

年：

2024

卷：

页码：

1386773

DOI：

10.3389/fendo.2024.1386773

基金类别：

Science and Technology Committee of China [2016YFC1305800]; Clinical Research Center of Regenerative Medicine of Hubei Province

机构署名：

本校为其他机构

院系归属：

医学与健康学院

摘要：

BackgroundOur previous multicenter case-control study showed that aging, up-regulation of platelet glycogen synthase kinase-3β (GSK-3β), impaired olfactory function, and ApoE ϵ4 genotype were associated with cognitive decline in type 2 diabetes mellitus (T2DM) patients. However, the causal relationship between these biomarkers and the development of cognitive decline in T2DM patients remains unclear.MethodsTo further investigate this potential relationship, we designed a 6-year follow-up study in 273 T2DM patients with normal cognitive in ou...

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Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study

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