Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study

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成果类型：

期刊论文

作者：

Wei, Wei;Xu, Pan;Li, Li;Mao, Hong;Li, Na;...

通讯作者：

Zhao, S

作者机构：

[Li, Li; Zhao, Shi; Wei, Wei; Li, Na; Mao, Hong] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China.

[Xu, Pan] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Neurol, Wuhan, Peoples R China.

[Wang, Xiao-qing] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Peoples R China.

[Wang, Li] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Nursing, Wuhan, Peoples R China.

[Xu, Zhi-peng] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med,Hubei Key Lab Neurol Disorders, Dept Pathophysiol,Minist Educ,Key Lab Neurol Disor, Wuhan, Peoples R China.

通讯机构：

[Zhao, S ] H

Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China.

语种：

英文

关键词：

Alzheimer’s disease;ApoE gene;glycogen synthase kinase-3β;mild cognitive impairment;type 2 diabetes mellitus

期刊：

FRONTIERS IN ENDOCRINOLOGY

ISSN：

1664-2392

年：

2024

卷：

页码：

1386773

DOI：

10.3389/fendo.2024.1386773

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The study was supported in parts by grants from Science and Technology Committee of China (2016YFC1305800) and Clinical Research Center of Regenerative Medicine of Hubei Province. The sponsors of the study neither played a role in the study design, implementation, data collection, analysis and interpretation nor participated in the manuscript’s preparation, review and approval. The corresponding author had full access to all study data in the study and had final responsibility for the decision to submit for publication.

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本校为其他机构

院系归属：

医学与健康学院

摘要：

Background Our previous multicenter case-control study showed that aging, up-regulation of platelet glycogen synthase kinase-3 beta (GSK-3 beta), impaired olfactory function, and ApoE & varepsilon;4 genotype were associated with cognitive decline in type 2 diabetes mellitus (T2DM) patients. However, the causal relationship between these biomarkers and the development of cognitive decline in T2DM patients remains unclear. Methods To further investigate this potential relationship, we designed a 6-year follow-up study in 273 T2DM patients with normal cognitive in our previous study. Baseline cha...

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Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study

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