Triple combination exposure to MPs, Pb2+ and As3+ induces ferroptosis at environmentally relevant concentrations in early development of zebrafish

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成果类型：

期刊论文

作者：

Cao, Yue;Yao, Xiangao;Zhu, Yuanren;Lu, Yue;Ding, Rui;...

通讯作者：

Fang, Min;Zhao, XL

作者机构：

[Ding, Rui; Zhu, Yuanren; Lu, Yue; Cao, Yue; Gong, Zhiyong; Wang, Qiao; Yao, Xiangao; Liu, Xin; Fang, Min; Xiao, Shensheng; Zhao, Xiaole] Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.

[Wen, Sheng] Hubei Prov Ctr Dis Control & Prevent, Wuhan 430079, Hubei, Peoples R China.

[Fang, Min; Zhao, Xiaole] Wuhan Polytech Univ, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Fang, M; Zhao, XL ] W

Wuhan Polytech Univ, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

Microplastics;Lead and Arsenic;Zebrafish;Triple combined exposure;Developmental responses

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2025

卷：

292

页码：

117942

DOI：

10.1016/j.ecoenv.2025.117942

基金类别：

National Key Research and Development Program of China [2022YFF1102500, 2023YFF1104601]; Wuhan Polytechnic University [2022RZ038]; Research and Innovation Initiatives of Wuhan Polytechnic University [2023Y12]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

There remains a substantial knowledge gap in understanding the coexistence effects of Microplastics (MPs), lead (Pb) and arsenic (As), which are ubiquitous environmental contaminants. Here, zebrafish ( Danio rerio ) embryos were used to investigate the impact of triple combined exposure to MPs (50 μg/L), Pb 2+ (10 μg/L) and As 3+ (200 μg/L) on the developmental responses. Survival and hatching rates were notably reduced to 32.7 % and 58.8 %, respectively. Meanwhile, the frequency of spontaneous tail contractions increased by 8.1 %, whe...

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Triple combination exposure to MPs, Pb2+ and As3+ induces ferroptosis at environmentally relevant concentrations in early development of zebrafish

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