Corn-derived peptide LQQQLL alleviates skeletal muscle attenuation by mTOR signaling pathway and intestinal microbiota

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成果类型：

期刊论文

作者：

Guo, Danjun;Zou, Hang;Chen, Mingyue;Wei, Siying;Cai, Yuxuan;...

通讯作者：

Xu, W

作者机构：

[Chen, Mingyue; Zou, Hang; Xu, Wei; Cai, Yuxuan; Yi, Yang; Guo, Danjun; Wei, Siying] Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.

[Wang, Hongxun; Chen, Mingyue; Zou, Hang; Cai, Yuxuan; Yi, Yang; Xu, Wei; Guo, Danjun; Wei, Siying] Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Peoples R China.

[Wang, Hongxun] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Peoples R China.

[Wang, Zhongjiang] Northeast Agr Univ, Coll Food Sci, Harbin 150030, Peoples R China.

通讯机构：

[Xu, W ] W

Wuhan Polytech Univ, Sch Food Sci & Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Corn peptides (CPs);Intestinal microbiota;LQQQLL;Sarcopenia;mTOR signaling pathway

期刊：

Food Research International

ISSN：

0963-9969

年：

2025

卷：

218

页码：

116872

DOI：

10.1016/j.foodres.2025.116872

基金类别：

CRediT authorship contribution statement Danjun Guo: Writing – original draft, acquisition, Conceptualization. Hang Zou: Investigation, Data curation. Mingyue Chen: Methodology, Investigation. Siying Wei: Software, Data curation. Yuxuan Cai: Investigation. Zhongjiang Wang: Writing – original draft, Data curation. Hongxun Wang: Project administration. Yang Yi: Resources. Wei Xu: Writing – review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

生命科学与技术学院

摘要：

A novel peptide attenuating skeletal muscle atrophy was prepared, identified, screened from corn and its molecular mechanism was explored using two-step enzymatic hydrolysis, molecular docking, and sarcopenia mice model. The results showed that the DPPH free radical scavenging rate of corn peptides (CPs) was 45.20 % under the optimum preparation conditions. Fifty-one peptide fragments were identified from CPs, among which QQPIVGGA, QYQLPSY, LQQQLL, and LQQQQL presented superior affinity with mTORC1 and FOXO in molecular docking. LQQQLL (0.02 ...

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Corn-derived peptide LQQQLL alleviates skeletal muscle attenuation by mTOR signaling pathway and intestinal microbiota

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