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Investigation of the inhibition effect of 1,2,3,4,6-pentagalloyl-β-D-glucose on gastric cancer cells based on a network pharmacology approach and experimental validation

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成果类型:
期刊论文
作者:
Bi, Jing-hui;Jiang, Yu-han;Ye, Shi-jie;Wu, Min-rui;Yi, Yang;...
通讯作者:
Wang, L.-M.
作者机构:
[Bi, Jing-hui; Wang, Hong-xun; Ye, Shi-jie; Wu, Min-rui; Jiang, Yu-han; Wang, Li-mei] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan, Peoples R China.
[Yi, Yang] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan, Peoples R China.
通讯机构:
[Wang, L.-M.] C
College of Life Science and Technology, Wuhan Polytechnic University, Wuhan, China
语种:
英文
关键词:
gastric cancer;mechanism;network pharmacology;p53 signaling pathway;β-PGG
期刊:
FRONTIERS IN ONCOLOGY
ISSN:
2234-943X
年:
2022
卷:
12
页码:
934958
基金类别:
This work was supported by the Primary Research & Development Plan of Hubei Province (2020BBB074, 2020BBA046).
机构署名:
本校为第一机构
院系归属:
食品科学与工程学院
生命科学与技术学院
摘要:
Background: Gastric cancer (GC) is ranked as the third leading cause of cancer-related mortality worldwide. 1,2,3,4,6-Pentagalloyl-β-D-glucose (β-PGG) has various pharmacological activities and has been shown to suppress cancer development. However, the mechanism by which β-PGG inhibits gastric cancer has not been elucidated. Objective: This study explored the potential targets and mechanism of β-PGG in GC using the network pharmacology approach combined with in-vitro experiments. Methods: The PharmMapper software was used to predict the po...

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