Exosomal ncRNAs profiling of mycobacterial infection identified miRNA-185-5p as a novel biomarker for tuberculosis

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成果类型：

期刊论文

作者：

Kaushik, Aman Chandra;Wu, Qiqi;Lin, Li;Li, Haibo;Zhao, Longqi;...

通讯作者：

Zhang, Shulin;Wei, Dongqing

作者机构：

[Kaushik, Aman Chandra] Shanghai Jiao Tong Univ, Shanghai, Peoples R China.

[Kaushik, Aman Chandra] Jiangnan Univ, Sch Med, Wuxi, Jiangsu, Peoples R China.

[Lin, Li; Guo, Xiaokui; Zhang, Shulin; Wu, Qiqi] Shanghai Jiao Tong Univ, Sch Med, Dept Immunol & Microbiol, Shanghai, Peoples R China.

[Wang, Hualin; Yu, Xiaoli; Li, Haibo; Zhao, Longqi] Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[Wen, Zilu; Song, Yanzheng; Wu, Qihang; Zhang, Shulin] Shanghai Publ Hlth Clin Ctr, Res Ctr TB, Shanghai, Peoples R China.

通讯机构：

[Zhang, Shulin; Wei, Dongqing] S

Shanghai Jiao Tong Univ, Sch Med, Dept Immunol & Microbiol, Shanghai, Peoples R China.

Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.

语种：

英文

关键词：

RNA-seq;circRNA–miRNA networks;exosome;miR-185-5p;mycobacteria

期刊：

BRIEFINGS IN BIOINFORMATICS

ISSN：

1467-5463

年：

2021

卷：

期：

DOI：

10.1093/bib/bbab210

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871613, 61832019, 61503244]; National Science and Technology Major Project [2017ZX10201301-003-001, 2016YFA050 1703]; Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [19430750600]; Shanghai Jiao Tong University School of Medicine Technology Transfer Project [ZT201917]; Youth Fund for Basic Research Project of Jiangnan University [JUSRP12049]

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Background: There are ever increasing researches implying that noncoded RNAs (ncRNAs) specifically circular RNAs (circRNAs) and microRNAs (miRNAs) in exosomes play vital roles in respiratory disease. However, the detailed mechanisms persist to be unclear in mycobacterial infection. Methods: In order to detect circRNAs and miRNAs expression pattern and potential biological function in tuberculosis, we performed immense parallel sequencing for exosomal ncRNAs from THP-1-derived macrophages infected by Mycobacterium tuberculosis H37Ra, Mycobacteri...

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Exosomal ncRNAs profiling of mycobacterial infection identified miRNA-185-5p as a novel biomarker for tuberculosis

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