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Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions

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成果类型:
期刊论文
作者:
Yao, Jinyi;Li, Keying;Fu, Zhenli;Zheng, Jingjing;Chen, Zicong;...
通讯作者:
Li, Nan
作者机构:
[Huang, Yaomin; Fu, Zhenli; Huang, Jinsheng; Han, Shuangxue; Li, Nan; Li, Keying; Yao, Jinyi; Lai, Guoqing; You, Guanying; Zheng, Jingjing; Liu, Qiong; Xu, Jiahao; Chen, Zicong] Shenzhen Key Laboratory of Marine Biotechnology and Ecology, Brain Disease and Big Data Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, China
[He, Zhijun] National R&D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan, China
[Liu, Qiong] Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China
[Li, Nan] Instrumental Analysis Center of Shenzhen University, Shenzhen, China
[Li, Nan] Shenzhen Bay Laboratory, Shenzhen, China. Electronic address: lin@szu.edu.cn
通讯机构:
[Nan Li] S
Shenzhen Key Laboratory of Marine Biotechnology and Ecology, Brain Disease and Big Data Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, China<&wdkj&>Instrumental Analysis Center of Shenzhen University, Shenzhen, China<&wdkj&>Shenzhen Bay Laboratory, Shenzhen, China
语种:
英文
关键词:
NAD(+);ROS;Tau;Warburg effect;aerobic glycolysis;mTOR;oxidative phosphorylation
期刊:
Journal of Biological Chemistry
ISSN:
0021-9258
年:
2025
页码:
108376
机构署名:
本校为其他机构
院系归属:
硒科学与工程现代产业学院
摘要:
The neurofilaments formed by hyperphosphorylated tau is a hallmark of tauopathies. However, the biological functions of tau and the physiological significance of its phosphorylation are still not fully understood. By using human tau (441 a.a.) transgenic (hTau) mice, murine tau knockout (Tau KO) mice and C57BL/6J (C57) mice, unexpectedly, we found that under acute hyperglycemia conditions, JNK but not previously reported GSK3β mediated tau phosphorylation. Moreover, Akt, the inhibitory kinase upstream of GSK3β, was activated in a tau dependen...

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