Comparison of metabolic rates of ropivacaine in cerebrospinal fluid as inferred from plasma concentrations between elderly patients and young patients

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成果类型：

期刊论文

作者：

Lu, Dongshi;Cai, Fei;Ming, Yu;Zhang, Danqing;Ba, Demu;...

通讯作者：

Wu, Zhouyang;Zhang, Z

作者机构：

[Wu, Zhouyang; Cai, Fei; Wu, ZY; Zhang, Danqing; Zhang, Zhao; Zhang, Z; Lu, Dongshi] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.

[Ming, Yu] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Peoples R China.

[Zhang, Zhao; Zhang, Z; Ba, Demu] Mongolian Autonomous Prefecture, Peoples Hosp Bortala, Bole City, Peoples R China.

通讯机构：

[Wu, ZY; Zhang, Z ] H

Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.

Mongolian Autonomous Prefecture, Peoples Hosp Bortala, Bole City, Peoples R China.

语种：

英文

关键词：

Ropivacaine;Cerebrospinal fluid (CSF);Hyaluronic acid (HA);Central lymphatic circulation (CLC);Postoperative cognitive dysfunction (POCD)

期刊：

Perioperative Medicine

ISSN：

2047-0525

年：

2024

卷：

期：

页码：

1-5

DOI：

10.1186/s13741-024-00372-0

基金类别：

This study was supported by the Science and Technology Department of Xinjiang Uygur Autonomous Region (2022D01F44) and Bethune Public Welfare Foundation (bnmr2021008).

机构署名：

本校为其他机构

院系归属：

医学与健康学院

摘要：

With the aging of human society, more and more elderly patients have to undergo surgery and anesthesia. Clinical observations have indicated from time to time that spinal anesthesia in the elderly appears to last longer than in young people, although there is limited research in this area and the mechanism is unclear at present time. This research work is expected to help understand the decline of local anesthetic metabolism in cerebrospinal fluid of elderly patients so as to help them with precise anesthesia and rapid rehabilitation. Twenty pa...

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Comparison of metabolic rates of ropivacaine in cerebrospinal fluid as inferred from plasma concentrations between elderly patients and young patients

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