期刊论文

中文

现代药物与临床

1674-5515

2021

36

02

226-230

10.7501/j.issn.1674-5515.2021.02.003

本校为第一机构

目的 研究茶黄素对高尿酸血症模型小鼠的降尿酸作用.方法 采用氧嗪酸钾诱导高尿酸血症小鼠模型,茶黄素低、中、高剂量(6、20、60 mg/kg)和别嘌呤(10 mg/kg)连续ig给药7 d,检测高尿酸血症小鼠血清尿酸(UA)、尿素氮(BUN)、肌酐(CRE)、天冬氨酸氨基转氨酶(AST)、丙氨酸氨基转氨酶(ALT)水平,评价茶黄素的降尿酸作用.结果 与对照组比较,模型组小鼠血清CRE、BUN、AST和ALT水平显著升高;与模型组相比,茶黄素中、高剂量组小鼠血清UA、CRE、BUN、AST、ALT水平显著降低(P

Objective: To study the reducing uric acid effect of theaflavins on hyperuricemia mice. Methods Hyperuricemia mice model was induced by potassium oxazinate. Theaflavins were fed to rats for 7 d with theaflavins at low, medium, and high doses (6, 20, and 60 mg/kg) and allopurinol (10 mg/kg) continuously. The serum uric acid (UA), urea nitrogen (BUN), creatinine (CRE), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels in mice were determined to evaluate the uric acid-lowering effect of theaflavins. Results Compared with ...