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Transport of Flavanolic Monomers and Procyanidin Dimer A2 across Human Adenocarcinoma Stomach Cells (MKN-28).

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成果类型:
期刊论文
作者:
Li, Shuyi;Li, Junsheng;Sun, Yiwei;Huang, Yuqi;He, Jingren;...
通讯作者:
Zhu, Zhenzhou
作者机构:
[Li, Shuyi; Li, Junsheng; Sun, Yiwei; Huang, Yuqi; He, Jingren; Zhu, Zhenzhou] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China
[Li, Shuyi; He, Jingren; Zhu, Zhenzhou] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China
通讯机构:
[Zhu, Zhenzhou] W
Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China. Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
(-)-epicatechin;LSCM;procyanidin A2;stomach barrier;transport efficiency
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN:
0021-8561
年:
2019
卷:
67
期:
12
页码:
3354-3362
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31501482, 21506166]; Hubei Province "One Hundred Talent Program"; Hubei Province "Chutian Scholar Plan"
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
It has been proven that A-type procyanidins, containing an additional ether bond, compared to B-type procyanidins are also bioavailable in vitro and in vivo. However, their bioavailability and absorption in the gastrointestinal tract remain uncertain. In this study, a model of the human adenocarcinoma stomach cell line (MKN-28) was established to explore the cellular transport of flavanolic monomers and procyanidin dimer A2, which were isolated from the litchi pericarp extract. After the integrity and permeability of the cell monolayer were ensured by measurement of the transepithelial electri...

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