Transport of Flavanolic Monomers and Procyanidin Dimer A2 across Human Adenocarcinoma Stomach Cells (MKN-28)

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成果类型：

期刊论文

作者：

Li, Shuyi;Li, Junsheng;Sun, Yiwei;Huang, Yuqi;He, Jingren;...

通讯作者：

Zhu, Zhenzhou

作者机构：

[Li, Shuyi; Li, Junsheng; Sun, Yiwei; Huang, Yuqi; He, Jingren; Zhu, Zhenzhou] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China

[Li, Shuyi; He, Jingren; Zhu, Zhenzhou] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China

通讯机构：

[Zhu, Zhenzhou] W

Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China. Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

Biochemistry;Cell culture;Cells;Dimers;Efficiency;High performance liquid chromatography;Mass spectrometry;Monomers;Epicatechin;LSCM;Procyanidin a2;stomach barrier;Transport efficiency;Flavonoids;biflavonoid;catechin;flavanone;flavanone derivative;plant extract;proanthocyanidin;procyanidin;adenocarcinoma;bioavailability;chemistry;dimerization;fruit;high performance liquid chromatography;human;lychee;metabolism;stomach mucosa;transport at the cellular level;tumor cell line;Adenocarcinoma;Biflavonoids;Biological Availability;Biological Transport;Catechin;Cell Line, Tumor;Chromatography, High Pressure Liquid;Dimerization;Flavanones;Fruit;Gastric Mucosa;Humans;Litchi;Plant Extracts;Proanthocyanidins

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2019

卷：

期：

页码：

3354-3362

DOI：

10.1021/acs.jafc.9b00378

基金类别：

*Fax: +86-27-83924790. E-mail: zhenzhouzhu@126.com. ORCID Zhenzhou Zhu: 0000-0002-8926-2300 Funding The authors appreciate the financial support of the National Natural Science Foundation of China (31501482 and 21506166) and the support of Hubei Province “One Hundred Talent Program” and “Chutian Scholar Plan”. Notes The authors declare no competing financial interest. The authors appreciate the financial support of the National Natural Science Foundation of China (31501482 and 21506166) and the support of Hubei Province One Hundred Talent Program and Chutian Scholar Plan.

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

It has been proven that A-type procyanidins, containing an additional ether bond, compared to B-type procyanidins are also bioavailable in vitro and in vivo. However, their bioavailability and absorption in the gastrointestinal tract remain uncertain. In this study, a model of the human adenocarcinoma stomach cell line (MKN-28) was established to explore the cellular transport of flavanolic monomers and procyanidin dimer A2, which were isolated from the litchi pericarp extract. After the integrity and permeability of the cell monolayer were ens...

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Transport of Flavanolic Monomers and Procyanidin Dimer A2 across Human Adenocarcinoma Stomach Cells (MKN-28)

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