Protectin DX ameliorates inflammation in sepsis-induced acute lung injury through mediating PPARγ/NF-κB pathway

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成果类型：

期刊论文

作者：

Xia, Haifa;Ge, Yangyang;Wang, Fuquan;Ming, Yu;Wu, Zhouyang;...

通讯作者：

Xiao, Weimin;Yao, Shanglong

作者机构：

[Wu, Zhouyang; Chen, Ming; Xia, Haifa; Wang, Fuquan; Xiao, Weimin; Wang, Jingxu; Yao, Shanglong; Ge, Yangyang; Huang, Shiqian; Xiao, WM; Sun, Shujun] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Peoples R China.

[Ming, Yu] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Peoples R China.

通讯机构：

[Xiao, WM; Yao, SL] H

Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Peoples R China.

Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Anesthesia & Crit Care, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.

语种：

英文

关键词：

Acute lung injury;NF-κB;Peroxisome proliferator-activated receptor gamma;Protectin DX;Sepsis

期刊：

Immunologic Research

ISSN：

0257-277X

年：

2020

卷：

期：

页码：

280-288

DOI：

10.1007/s12026-020-09151-7

基金类别：

This study was supported by the grants from the National Natural Science Foundation of China (No.81701887; No.81671890) and the Scientific Research Projects of Hubei Education Department (B2016081).

机构署名：

本校为其他机构

院系归属：

医学与健康学院

摘要：

Previous reports have demonstrated that the newly identified lipid mediator protectin DX (PDX) could effectively attenuate multiple organ injuries in sepsis. The aim of our study was to clarify whether PDX could improve acute lung injury (ALI) induced by sepsis and elucidate the relevant potential mechanism. After inducing sepsis by the cecal ligation and puncture approach, mice were treated with a high or low dose of PDX. Pathological changes in the pulmonary tissue were analyzed by hematoxylin-eosin staining, and lung injury score was evaluat...

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Protectin DX ameliorates inflammation in sepsis-induced acute lung injury through mediating PPARγ/NF-κB pathway

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