期刊论文

Liu, L

英文

Journal of Drug Delivery Science and Technology

1773-2247

2024

92

105376

10.1016/j.jddst.2024.105376

CRediT authorship contribution statement Mengying Wang: Formal analysis, Investigation, Methodology, Validation, Writing – original draft. Yanlin Sun: Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – review & editing. Mingjie Wang: Formal analysis, Methodology, Validation. Zhaojun Yang: Investigation, Methodology. Yong Shi: Investigation, Methodology. Dong Zeng: Data curation, Supervision. Liang Liu: acquisition, Resources, Supervision.

本校为第一且通讯机构

Due to the powerful DNA loading capacity and excellent proton sponge effect, the cationic polymer polyethyleneimine (PEI) has been demonstrated as a versatile, efficient DNA delivery tool both in vitro and in vivo. However, the excess surface positive charge of PEI and the common capture/clearance of PEI/DNA complex by the immune system limit its further clinical applications. To reduce the cytotoxicity resulting from surface charge and avoid the clearance of nanoparticles interacting with proteins and circulating immune cells in the blood, a bionic gene delivery system was developed by coatin...