期刊论文

Zhang, YY

英文

Frontiers in Veterinary Science

2297-1769

2023

10

1280161

10.3389/fvets.2023.1280161

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the National Natural Science Foundation of China (32102674 and 32202814), Hubei Province Education [32102674, 32202814]; National Natural Science Foundation of China [Q20211604]; Hubei Province Education Department Scientific Research Item [2020Y16]; School Research Projects of Wuhan Polytechnic University [2021R2020]; Wuhan Polytechnic University [202314]; Open Project Of Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University

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The deletion of orphan response regulator CovR reduces the growth rate of Streptococcus suis serotype 2 (S. suis 2). In this study, metabolome and transcriptome profiling were performed to study the mechanisms underlying the poor growth of S. suis 2 caused by the deletion of orphan response regulator CovR. By comparing S. suis 2 (Delta covR) and S. suis 2 (SC19), 146 differentially accumulated metabolites (upregulated: 83 and downregulated: 63) and 141 differentially expressed genes (upregulated: 86 and downregulated: 55) were identified. Metabolome and functional annotation analysis revealed ...