Interaction of the transforming growth factor- and Notch signaling pathways in the regulation of granulosa cell proliferation

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成果类型：

期刊论文

作者：

Sun, Xiao-Feng;Sun, Xing-Hong;Cheng, Shun-Feng;Wang, Jun-Jie;Feng, Yan-Ni;...

通讯作者：

Zhang, Xi-Feng

作者机构：

[Hou, Zhu-Mei; Yin, Shen; Feng, Yan-Ni; Sun, Xiao-Feng; Sun, Xing-Hong; Zhao, Yong; Shen, Wei; Cheng, Shun-Feng; Wang, Jun-Jie] Key Lab Anim Reprod & Germplasm Enhancement Unive, Qingdao 266109, Peoples R China.

[Sun, Xiao-Feng] Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China.

[Yin, Shen; Feng, Yan-Ni; Sun, Xing-Hong; Zhao, Yong; Shen, Wei; Cheng, Shun-Feng; Wang, Jun-Jie] Qingdao Agr Univ, Coll Anim Sci & Technol, Qingdao 266109, Peoples R China.

[Hou, Zhu-Mei] Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Peoples R China.

[Zhang, Xi-Feng] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

通讯机构：

[Zhang, Xi-Feng] W

Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

activin A;cross-talk

期刊：

Reproduction, Fertility and Development

ISSN：

1031-3613

年：

2016

卷：

期：

页码：

1873-1881

DOI：

10.1071/RD14398

基金类别：

National Nature Science FoundationNational Natural Science Foundation of China (NSFC) [31101716, 31471346]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-12-1026]; Nature Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2013CQ029]

机构署名：

本校为通讯机构

院系归属：

生命科学与技术学院

摘要：

The Notch and transforming growth factor (TGF)-β signalling pathways play an important role in granulosa cell proliferation. However, the mechanisms underlying the cross-talk between these two signalling pathways are unknown. Herein we demonstrated a functional synergism between Notch and TGF-β signalling in the regulation of preantral granulosa cell (PAGC) proliferation. Activation of TGF-β signalling increased hairy/enhancer-of-split related with YRPW motif 2 gene (Hey2) expression (one of the target genes of the Notch pathway) in PAGCs, a...

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Interaction of the transforming growth factor- and Notch signaling pathways in the regulation of granulosa cell proliferation

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